
PayRio delivers specialized payment processing for businesses operating in regulated, emerging, and alternative wellness markets. From cannabis and cannabinoids to research peptides, functional mushrooms, and licensed treatment centers, we help forward-thinking companies move money seamlessly and compliantly.
Whether you’re launching something new or scaling an established operation, PayRio provides modern, secure, and reliable payment solutions built to support growth in complex industries. Focus on innovation—we’ll handle the payments.
At PayRio, our mission is to simplify and strengthen payment processing for alternative and emerging wellness industries. We exist to remove the financial and operational barriers that have historically limited these markets, delivering secure, efficient, and cost-effective payment solutions built for complex environments.
As a provider purpose-built for regulated wellness sectors, we advocate for our clients by offering reliable infrastructure, responsive support, and real industry expertise. Everything we do is focused on empowering our partners, supporting long-term growth, and helping shape the future of wellness payments.

Finding Aubrey at PayRio was a total game-changer. From the first conversation, it was clear she genuinely cares, and the entire team reflects that same energy! Libby made onboarding effortless, and they handled the credit card processing setup for my e-commerce site with such clarity and ease. After dealing with a few other providers, working with PayRio felt like a breath of fresh air. Highly recommend.


At PayRio, we offer exceptional stability, transparency, and support tailored to businesses operating in ‘high-risk’ industries. Our extensive experience enables us to understand the challenges you face, and our payment solutions are specifically designed to address these issues. With PayRio, you’re not just getting a payment processor; you’re gaining a partner who’s invested in the growth of your business.
At PayRio, we provide stable, transparent, and reliable payment solutions for businesses operating in high-risk and regulated industries. Our deep industry experience allows us to anticipate the challenges our clients face and design solutions that address them directly. With PayRio, you’re not just choosing a payment processor—you’re gaining a trusted partner committed to supporting your growth every step of the way.
We deliver industry-leading uptime because every transaction and every second matters. Downtime is not just inconvenient; it can directly affect your revenue and your reputation. That is why we work with multiple banking partners that actively support high-risk and alternative medicine industries, providing built-in redundancy and long-term stability you can rely on.
Our merchants benefit from hands-on expertise designed to mitigate risk and maintain compliance. Our in-house specialists hold certifications across industry-specific verticals, risk and compliance, and the broader payments ecosystem, and we continuously refine our knowledge to stay ahead of evolving requirements.
Every client is paired with a dedicated Customer Success Manager who guides onboarding and remains the primary point of contact throughout the relationship. This personalized approach ensures consistent communication, proactive support, and a true partnership focused on long-term success.
When you contact PayRio, you will never be routed to a call center. You’ll speak directly with a knowledgeable team that understands your business and is ready to help. Whether you need guidance, have a question, or require immediate assistance, our team is always just a call or email away.
At PayRio, transparency comes first. We believe merchants should have a clear and complete understanding of their payment processing provider and costs. Our pricing models—including Flat, Interchange Plus, and Dual Pricing—are designed to offer flexibility while clearly outlining fees upfront. This ensures full visibility into transaction expenses, with no hidden costs and no surprises.
Whether you’re launching a new venture or operating an established enterprise, PayRio is here to support you as your business grows. We scale payment processing alongside your operations, developing custom solutions aligned with your unique needs and regulatory requirements. Our team works closely with you to understand your goals and challenges, delivering tailored strategies that help your business operate efficiently and thrive.
We are a full-service payment processor equipped to manage every stage of the transaction lifecycle, from sales and document intake to expedited underwriting, merchant support, and ongoing monitoring and compliance. Our payment solutions integrate seamlessly with all major processing gateways, ensuring a fast, disruption-free onboarding experience with no downtime. This end-to-end approach allows our merchants to focus on growing their business while we handle the complexities behind the scenes.
Contact us today to learn more about how PayRio can support the growth of your business and streamline your transactions.
Together, we can pave the way for a future where secure, compliant, & scalable payment processing is a reality for all businesses
in the various alternative medicine sectors. We are more than just a payment processor, we are a trusted partner dedicated to
your growth and success.

For:20 Minutes is a blog focused on the Cannabis community and Cannabis normalization. Writer Amanda Ferron (@canna_panda_) has been a medicinal Cannabis consumer for 20 years, and in the legal CA Cannabis industry for almost 10. Read along as she discusses everything Cannabis! Events, culture, people, products, brands… and more!
Welcome to Higher Education, a dynamic and informative blog dedicated to empowering business owners in the ever-evolving cannabis and alternative medicine industries. Our goal is to provide you with the knowledge, insights, and resources you need to navigate the unique challenges and opportunities within these rapidly growing sectors.
EXCELLENT Based on 118 reviews Posted on Google Charles HartmanTrustindex verifies that the original source of the review is Google. Great people. Great service.Posted on Google Joni MiyagiTrustindex verifies that the original source of the review is Google. PayRio offers amazing customer service for business owners and I’m loving them for my store so far. Thank you!Posted on Google Kaveh GorganiTrustindex verifies that the original source of the review is Google. My company has been working with PayRio for almost a year, and have been very happy with them as a company. From day 1 their customer service has gone above and beyond, and I look forward to continuing my business relationship with them. I happily give them 5 stars, and definitely recommend them for anyone who is in need of payment processing services.Posted on Google Farid HarrisonTrustindex verifies that the original source of the review is Google. The PayRio team has been an incredible partner for us! Their entire team is always available and the impact that their solutions have had on our team and business in general are incalculable. We would highly recommend Aubrey and her team!!Posted on Google ColdFire SalesTrustindex verifies that the original source of the review is Google. Working with Chase at PayRio has been very pleasant. Chase has been extremely helpful and understanding of our needs. He made the time to meet immediately when we first got connected through referral. He also took the time to evaluate what we were currently paying with our current/former credit card processor and broke down the savings and benefits of working with PayRio. Looking forward to working together!Posted on Google Samantha YusonTrustindex verifies that the original source of the review is Google. We have been working with PayRio for the last couple of years, and it has consistently been an amazing experience. Aubrey and Cameron, in particular, have been wonderful and kind to work with. They have played a significant role in helping our business grow.Posted on Google Brennan BuranTrustindex verifies that the original source of the review is Google. I met Aubrey and some of her staff from PayRio about a year ago. I work with them on a different scale but from day 1 they have always treated me with kindness, respect and compassion. Always attentive to everyone’s needs, the PayRio staff is always willing to go the extra mile for their customers. Everytime I walk into the office, Aubrey is usually on a video call helping or marketing her brand that she is so passionate and proud of, one that she built from the ground up. I would highly recommend PayRio for all of you’re payment solutions. They are building something special. Don’t miss out!!Posted on Google marcia fieldTrustindex verifies that the original source of the review is Google. Professional, responsive, and reliable. Everything you want in a payment processorPosted on Google Daniel CrawfordTrustindex verifies that the original source of the review is Google. Chase and the PayRio team are true professionals. They are quick to respond and to provide accurate answers to keep the process rolling.Posted on Google Simple Pleasure'sTrustindex verifies that the original source of the review is Google. Chase was a huge part of our success in the launching of our new website. Without him and PayRio we would have been set back majorly. They were a pleasure to work with and i won’t hesitate to reach out to them for future needs and referrals.